During the weeks leading up to the realease of Blade: Trinity, the third (and final) installment of the Blade series rumours began of a spin off movie for "The Nightstalkers". It was never confirmed if either Jessica or Ryan Reynolds would star but it was very much talked about and seemed like it would be likely to happen. However with the bomb of the last movie it didn't seem like it would ever happen. If it ever did it would likely not to have either Ryan or Jessica in it.

"I think that's over with. Nothing ever came really with the Night Stalkers. I actually thought that, maybe we would do an adaptation of that, but I just don't think that Blade: Trinity did so well. It just didn't do as well as everyone would have hoped, so no one was interested in rethinking those characters. But I'm open to it; I'm open to other comic book adaptations or big action. I mean, I like action movies, I like doing action movies, I think they're fun." - Jessica